The creator of This Is Us has made a movie called Life Itself, so yeah, get ready to have your heart ripped out.

From writer/director Dan Fogelman, the movie is about “people from New York to Spain whose lives intersect over the course of different generations” and has an all-star cast including Oscar Isaac, Olivia Wilde, Antonio Banderas, Olivia Cooke, Mandy Patinkin and Alex Monner.

Watch the trailer!

Life Itself, from Amazon Studios, will be released in theaters on September 21.